This show follows the nights of the detectives working at the Las Vegas Police Department Crime Scene Investigations bureau. Being the second busiest crime lab in America, CSI officers use the best scientific and technical methods to solve puzzles and catch criminals.

Ethan longs to escape his small Southern town. He meets a mysterious new girl, Lena. Together, they uncover dark secrets about their respective families, their history and their town.

A modern take on the cases of Sherlock Holmes, with the detective now living in New York City.

Sassy, streetwise Max works two jobs just to get by, one of which is waiting tables during the night shift at the retro-hip Williamsburg Diner. Sophisticated Caroline is an uptown trust fund princess who's having a run of bad luck that forces her to reluctantly give waitressing a shot. At first, Max sees Caroline as yet another in a long line of inept servers she must cover for, but she's surprised to find that Caroline has as much substance as she does style. When Caroline discovers Max's knack for baking amazing cupcakes, she sees a lucrative future for them, but they first need to raise the start-up money.

A thief with a unique code of professional ethics is double-crossed by his crew and left for dead. Assuming a new disguise and forming an unlikely alliance with a woman on the inside, he looks to hijack the score of the crew's latest heist.

The Harper brothers Charlie and Alan are almost opposites but form a great team. They have little in common except their dislike for their mundane, maternally cold and domineering mother, Evelyn. Alan, a compulsively neat chiropractor and control-freak, is thrown out by his manipulative wife Judith who nevertheless gets him to pay for everything and do most jobs in the house. Charlie is a freelance jingle composer and irresistible Cassanova who lives in a luxurious beach-house and rarely gets up before noon. Charlie "temporarily" allows Alan and his son Jake, a food-obsessed, lazy school kid who shuttles between his parents, to move in with them after Alan's separation/divorce. The sitcom revolves around their conflicting lifestyles, raising Jake (who has the efficient, caring dad while having a ball with his fun-loving sugar uncle who teaches him boyish things), and bantering with Evelyn and various other friends and family. Other fairly regular characters include Charlie's cleaning lady Berta and his rich, self-confessed stalker neighbor Rose who often sneaks in to spy on Charlie.