Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment next to Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

Bob's Burgers centers on the Belcher family (consists of Bob, Linda, Tina, Gene and Louise) who own a hamburger restaurant. Bob's burgers are really delicious and appear to be better than his rivals' but when it comes to selling burgers, his kids aren't really helpful, as more customers head over to Jimmy Pesto's restaurant.

The Griffin household includes two teenagers, a cynical dog who is smarter than everyone else, and an evil baby who makes numerous attempts to eradicate his mother. Heading up this eclectic household is Peter Griffin. Peter does his best to do what's right for the family, but along the way, he makes mistakes that are the stuff of legends.

Sparks fly when Wade Walker crashes the Peeples annual reunion in the Hamptons to ask for their precious daughter Grace's hand in marriage.

A detective from the year 2077 finds herself trapped in present day Vancouver and searching for ruthless criminals from the future.

One of the few remaining drone repairmen assigned to Earth, its surface devastated after decades of war with the alien Scavs, discovers a crashed spacecraft with contents that bring into question everything he believed about the war, and may even put the fate of mankind in his hands.