The Griffin household includes two teenagers, a cynical dog who is smarter than everyone else, and an evil baby who makes numerous attempts to eradicate his mother. Heading up this eclectic household is Peter Griffin. Peter does his best to do what's right for the family, but along the way, he makes mistakes that are the stuff of legends.

Jay Pritchett sits at the head of a large and unconventional family. Now in his second marriage to his gorgeous young wife, Gloria, Jay has been given something of a second chance. Still, old habits are hard to break, and it's trial by fire as he tries to adapt to life with the same passion and vigor that Gloria exhibits, which are matched by her precocious 12-year-old son, Manny. There are some culture clashes, a few misunderstandings, but also plenty of sweet victories along the way. Jay's grown daughter, Claire, and her husband, Phil, are the proud parents of three kids with whom they want that open, healthy, honest relationship. It's not always easy, especially when you have Haley, a teenage daughter who's growing up a little fast, Alex, a too-smart-for-her-own-good middle daughter and Luke, a scatterbrained boy. Add to this that Phil is just a big kid himself, even if he does always have the best intentions. Claire is the anchor, trying her best to run a tight ship and determined not to let her kids have the rebellious childhood she had. Claire's brother and Jay's grown son, Mitchell, is busy raising an adopted daughter, Lily, with his long term partner, Cameron. Opposites attract in this household, with Cameron having a wonderfully big personality and maybe a flare for the dramatic, while Mitchell is more buttoned-down. They balance each other out, and these doting fathers are relishing their roles as parents developing their own little family.

Daniel Holden must put his life back together after serving 19 years on Georgia's Death Row before DNA evidence calls his conviction into question.

A drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.

Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment next to Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

Emily Taylor, despite being reunited with her husband from prison, becomes severely depressed with emotional episodes and suicide attempts. Her psychiatrist, Jonathan Banks, after conferring with her previous doctor, eventually prescribes an experimental new medication called Ablixa. The plot thickens when the side effects of the drug lead to Emily killing her husband in a "sleepwalking" state. With Emily plea-bargained into mental hospital confinement and Dr. Banks' practice crumbling around him, the case seems closed. However, Dr. Banks cannot accept full responsibility and investigates to clear his name. What follows is a dark quest that threatens to tear what's left of his life apart even as he discovers the diabolical truth of this tragedy.