Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment next to Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

The year is 2030. Ted Mosby is relaying the story of how he met his wife to his daughter and son. The story starts in the year 2005, when then twenty-seven year old architect Ted was spurred on to want to get married after lawyer Marshall Eriksen and kindergarten teacher Lily Aldrin, his best friends from their college days at Wesleyan and Marshall who was his roommate at the time, got engaged after nine years of dating each other. Ted's new quest in life was much to the dismay of his womanizing friend, Barney Stinson. But soon after Marshall and Lily's engagement, Ted believed that his life mate was going to be news reporter and aspiring news anchor Robin Scherbatsky, who, despite having had a romantic relationship with her after this time, ended up being who the kids know as their "Aunt" Robin. As Ted relays the story to his kids, the constants are that their Uncle Marshall, Aunt Lily, Uncle Barney and Aunt Robin are always in the picture and thus have something to do with how he got together with their mother.

The Griffin household includes two teenagers, a cynical dog who is smarter than everyone else, and an evil baby who makes numerous attempts to eradicate his mother. Heading up this eclectic household is Peter Griffin. Peter does his best to do what's right for the family, but along the way, he makes mistakes that are the stuff of legends.

Providing comedy/news in the tradition of TV Nation and SNL's Weekend Update, Comedy Central's Daily Show reports on the foibles and of the real world with a satirical edge. In addition to news stories, the Daily Show also has celebrities (and semi-celebrities) on for interviews with the host, Jon Stewart. Lampooning everything from televangelists to Charlton Heston ("I did not play a homo in Ben-Hur"), and shamelessly assigning faux-news epithets ("Newt Gingrich: Giant Toddler") Kilborn, Winstead, and the crew actually manage to report some real news from time to time.

The Simpsons is an animated sitcom about the antics of a dysfunctional family called the Simpsons (surprise surprise). Homer is the oafish unhealthy beer loving father, Marge is the hardworking homemaker wife, Bart is the ten year old underachiever (and proud of it), Lisa is the unappreciated eight year old genius, and Maggie is the cute, pacifier loving silent infant.

Six young people, on their own and struggling to survive in the real world, find the companionship, comfort and support they get from each other to be the perfect antidote to the pressures of life.

The Harper brothers Charlie and Alan are almost opposites but form a great team. They have little in common except their dislike for their mundane, maternally cold and domineering mother, Evelyn. Alan, a compulsively neat chiropractor and control-freak, is thrown out by his manipulative wife Judith who nevertheless gets him to pay for everything and do most jobs in the house. Charlie is a freelance jingle composer and irresistible Cassanova who lives in a luxurious beach-house and rarely gets up before noon. Charlie "temporarily" allows Alan and his son Jake, a food-obsessed, lazy school kid who shuttles between his parents, to move in with them after Alan's separation/divorce. The sitcom revolves around their conflicting lifestyles, raising Jake (who has the efficient, caring dad while having a ball with his fun-loving sugar uncle who teaches him boyish things), and bantering with Evelyn and various other friends and family. Other fairly regular characters include Charlie's cleaning lady Berta and his rich, self-confessed stalker neighbor Rose who often sneaks in to spy on Charlie.

Stan Smith, who works for the CIA and is constantly on the alert for terrorist activity. Stan will go to extremes to protect his beloved America from harm; as evidenced by the terror-alert color code on his fridge, and his frequent knee-jerk reaction of shooting holes in the toaster whenever the toast pops up. In addition to Stan's wife and teenage children, the Smith household has two rather unconventional members. There's Roger, the sarcastic space alien who rescued Stan from Area 51 who deeply resents the fact that he's not allowed to leave the house, and therefore, has been reduced to drinking wine and smoking cigarettes, and Klaus, a lascivious, German-speaking goldfish; the result of a CIA experiment gone seriously wrong where the CIA tried to give a fish a German man's brain. Stan's son is a dorky teenager who tries to be cool. His wife has had a past life of sex and drugs.

Jess - a bubbly offbeat teacher who is known to burst into spontaneous song - catches her boyfriend with another woman, and needs a new place to live. She moves into a loft with three single guys she's never met before. Nick is a jaded law-school dropout, who usually just wants to be left alone. Schmidt is an flashy businessman, who believes he is a gift to women. Winston is a former athlete who doesn't know what to do, but really needs to win whatever it is. Can this dysfunctional group handle the "adorkable" new girl?

When a High School Spanish teacher, Will Schuester, becomes the director of the school's failing Glee club, New Directions, he hopes to be able to rejuvenate it. The club competes in the choir competition circuit. It's been called "a High School Musical for adults", the series follows the club and its mixture of oddball members as they try and restore it to its former glory. It is a musical comedy in which the eager and ambitious students not only compete to win the Nationals, but also have to deal with the tough and cruel realities of their school, McKinley High. At the same time, Will is trying to rejuvenate his failing love life whilst preventing the school's cheer leading coach Sue Sylvester from sabotaging the choir.